Development of Analytical Methods for Microbial Volatile Organic Compounds (MVOC) in Biological Matrices: Evaluation of MVOCs as Mold Exposure Biomarkers Abstract Indoor air quality is a major occupational health and safety issue. Some studies have gone so far as to say that almost half the symptoms associated with poor indoor air quality are attributable to exposure to mold.A previous research activity identified 20 microbial volatile organic compounds (MVOC) emitted by molds that are harmful to health and that could be used as biomarkers of mold exposure in the workplace.The primary objective of this study is to develop an analytical method to measure these volatile organic compounds in the blood matrix, urine, exhalate and ambient air. A second objective is to measure the blood/air and urine/air partition coefficients for these MVOCs, which are very informative toxicokinetic parameters. Produced Under this Project Scientific Reports Développement de méthodes analytiques pour les composés organiques volatils microbiens (COVM) dans les matrices biologiques : vers l’évaluation des COVM comme biomarqueurs d’exposition aux moisissures Research Report: R-1188-fr Scientific Publications Development and validation of a method for the simultaneous quantification of 21 microbial volatile organic compounds in ambient and exhaled air by thermal desorption and gas chromatography–mass spectrometryTabbal S., El Aroussi B., Bouchard M., Geneviève Marchand, Haddad S.Source : (2022). Atmosphere, 13. doi: 10.3390/atmos13091432Determination of blood:air, urine:air and plasma:air partition coefficients ofselected microbial volatile organic compoundsBerkane W., El Aroussi B., Bouchard M., Geneviève Marchand, Haddad S.Source : (2023). Chemosphere, 343, 140305. doi: 10.1016/j.chemosphere.2023.140305 Other Project(s) You May be Interested in Use of Microbial Volatile Organic Compounds (MVOCs) as Exposure Biomarkers for Mould in the Workplace – Knowledge Summary Additional Information Type: Project Number: 2018-0021 Status: Completed Year of completion: 2023 Research Field: Chemical and Biological Hazard Prevention Team: Sami Haddad (Université de Montréal)Geneviève Marchand (IRSST)Michèle Bouchard (Université de Montréal)