Development and Application of an Approach for Evaluating the Exposure of Agricultural Workers to Pyrethroids Abstract Pyrethroids are among the most used pesticides in agriculture in Québec. During spreading or work carried out in treated areas, workers can be exposed, but very little information exists about the doses actually absorbed. This study proposes developing, validating and applying a toxicokinetic exposure evaluation approach to this type of pesticide and the risks that compromise workers’ health. The project has three steps: a kinetic study under medical surveillance on volunteers exposed to two of the most used pyrethroids, namely permethrin and cypermethrin; refinement of the toxicokinetic models; and a biological monitoring study in the work environment.The researcher wants to identify the most hazardous activities, guide preventive actions, and formulate recommendations to limit exposure. Produced Under this Project Scientific Reports Development and Application of a Toxicokinetic Approach to Assess Exposure of Agricultural Workers to Pyrethroids Research Report: R-936 Guide and Tools Pesticides - Safe practices and personal protective equipment (PPE) Awareness-raising document: DS-1000, DS-1004, DS-1007 Video Reports and Conferences Measurement of the exposure of workers to pesticides Conference: CF-208 Simplified Articles PesticidesQuel équipement de protection individuelle choisir Volume 31, n0 2Travail agricole et pesticidesSe donner les moyens d'évaluer l'exposition et les risques pour la santé Volume 30, n0 1 Scientific Publications Comparison of the toxicokinetic modeling of permethrin and cypermethrin biomarkers of exposureCôté J., Bouchard M.Source : in Annual Meeting of the Society of Toxicology, (53rd, March 23-27, 2014, Phoenix, USA), The Toxicologist, vol. 138, no 1, p. 17Metabolomic analysis of the effect of occupational exposure to pyrethroid pesticidesRatelle M., Bouchard M., Lin C.Source : in Annual Meeting of the Society of Toxicology, (53rd, March 23-27, 2014, Phoenix, USA), The Toxicologist, vol. 138, no 1, p. 400Importance of toxicokinetics in understanding and interpreting biological monitoring resultsBouchard M.Source : in International Symposium on Biological Monitoring / ISBM, (9th : September 9-11, 2013 : Manchester U.K.), 2013Time profiles of permethrin métabolites in orally exposed volunteers (Poster)Ratelle M., Côté J., Bouchard M.Source : in International Symposium on Biological Monitoring / ISBM, (9th : September 9-11, 2013 : Manchester U.K.), 2013Concentration profiles of chemical contaminants and their métabolites in humansBouchard M.Source : in International Symposium on Profiling / ISPROF 2013, (1st : September 2-4, 2013 : Lisbonne, Portugal), 2013Comparison of toxicokinetic parameters of cypermethrin and permethrin exposure biomarkers in orally exposed volunteers (Poster)Ratelle M., Bouchard M.Source : in Les paradigmes mécanistes pour la réglementation toxicologique : Symposium annuel de la Société de toxicologie du Canada, (45e : 3-5 décembre, 2013 : Ottawa, Canada), 2013Développement et application d'une approche pour toxicocinétique pour l'évaluation de l'exposition des travailleurs agricoles aux pyréthrinoïdesBouchard M.Source : Communication présentée au Rendez-vous de la science de l'IRSST, Montréal, QC.Toxicokinetics of permethrin biomarkers of exposure in orally exposed volunteersRatelle M., Côté J., Bouchard M.Source : (2015). Toxicology Letters, 232(2), 369-375. doi: 10.1016/j.toxlet.2014.12.003Time profiles and toxicokinetic parameters of key biomarkers of exposure to cypermethrin in orally exposed volunteers compared with previously available kinetic data following permethrin exposureRatelle M., Côté J., Bouchard M.Source : (2015). Journal of Applied Toxicology, 35(12), 1586-1593. doi: 10.1002/jat.3124 Other Project(s) You May be Interested in The Impact of Pesticide Co-Exposure on Biomarkers of Exposure to Pyrethroid Insecticides in Agricultural WorkersLambda-cyhalothrin as a preferred agricultural insectide: investigation of biomarker toxicokinetics for monitoring worker exposure Additional Information Type: Project Number: 2010-0009 Status: Completed Year of completion: 2016 Research Field: Chemical and Biological Hazard Prevention Team: Michèle Bouchard (Université de Montréal)