Determinants of long-term disability in workers with low back pain participating in a rehabilitation program: Exploratory study of the role of the immune and endocrine systems Abstract Work-related musculoskeletal disorders pose a major and costly problem for affected people as well as for all of society. This is primarily the case for non-specific low back pain, related to a long-term disability, which is impossible to diagnose. Several studies have demonstrated the importance of psychosocial factors in the onset and prognosis of musculoskeletal disorders, but few data exist on the physiological mechanisms that could explain such associations. In the case of other health problems (e.g., multiple sclerosis and inflammatory diseases), research has established the existence of links between certain physiological parameters and some psychosocial variables such as chronic stress and symptoms of depression and anxiety. This project is the continuation of a previous study on understanding the determinants of chronic disability, and aims to provide a better understanding of this phenomenon in the case of non-specific low back pain by exploring the relationship between psychological factors (pain, disability and distress) and the response of the immune and endocrine systems. It will test the hypothesis that major stress factors, including low back pain, weaken the body’s defenses, making it more vulnerable to disability following an injury. Produced Under this Project Scientific Reports Exploratory study of the role of the immune and endocrine systems in long-term disability following low back pain Research Report: R-708 Scientific Publications Étude de la réponse matinale de cortisol chez les travailleurs en arrêt de travail pour cause de lombalgie (Affiche)Gouin M.-M., Truchon M.Source : in Ensemble pour faire la différence : Journée scientifique et professionnelle de l'Institut de réadaptation en déficience physique de Québec / IRDPQ (5 juin, 2009 : Québec, Canada), 2009Étude de la réponse matinale de cortisol chez les travailleurs en arrêt de travail pour cause de lombalgie (Affiche)Truchon M., Gouin M.-M.Source : in La réadaptation à tout âge : enfants/adolescents, adultes/ainés : Journée scientifique annuelle conjointe CIRRIS-CRIR, (27 avril, 2009 : Montréal, Canada), 2009Role of immunological and endocrine systems in low-back pain related long-term disability: an exploratory studyTruchon M., Pouliot M., Filion L., Schmouth M. E., Gouin M. M., D'Amours B.Source : in Work, Stress, and Health 2009: Global Concerns and Approaches, (November 5-8, 2009 : San Jan, Puerto Rico), 2009 Other Project(s) You May be Interested in Factors that Influence a Sense of Injustice Following a Workplace Accident Additional Information Type: Project Number: 0099-7380 Status: Completed Year of completion: 2011 Research Field: Occupational Rehabilitation Team: Manon Truchon (Institut de réadaptation en déficience physique de Québec)Marc Pouliot (Université Laval)Marie-Ève Schmouth (Centre interdisciplinaire de recherche réadaptation et intégration sociale)Marie-Michelle Gouin (Université Laval)Ginette Truchon (IRSST)