IRSST - Institut de recherche Robert-Sauvé en santé et en sécurité du travail

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November 27, 2024

Literature review – Chemical substances and effect on hearing

Abstract

In the context of a systematic literature analysis on chemical substances and their effects on hearing, the authors evaluated the rigour of the methodologies used for measuring these effects and examined the consistency and differences that existed between studies on a given substance. They then developed a “decision grid” for making a judgment on the strength of proof of a causal relationship between exposure to the substances studied and the impact on hearing. The studied substances were classified according to four types of conclusions: the substance is ototoxic; it is possibly ototoxic; its ototoxicity has not been conclusively proven; there is no proof of ototoxicity. According to this method, ototoxic substances are: lead, styrene, toluene and trichloroethylene. Substances that are possibly ototoxic are: ethylbenzene, n-hexane and xylene.

The authors conclude that follow-up on the auditory system of workers exposed to substances belonging to the first two categories is relevant. They also believe that the possible interaction between exposure to these substances and noise is a factor to be considered in the development of prevention and worker follow-up programs.

Produced Under this Project

  • Évaluation des agents ototoxiques et leur interaction avec le bruit dans les milieux de travail

    Lim S., Leroux T., Truchon G., Vyskocil A.

    Source :

    in L'esprit en mouvement : 75e congrès de l'Association francophone pour le savoir / ACFAS, (75e : 7-11 mai, 2007 : Trois-Rivières, Canada), 2007

  • Effects of occupational exposure to chemicals on hearing - a weight of evidence approach

    Vyskocil A., Truchon G., Leroux T., Lemay F., Lim S., Gagnon F., Gendron M., El Majidi N., Viau C.

    Source :

    in Society of Toxicology Annual Meeting and ToxExpo (47th : March 16-20, 2008 : Seattle, United States), 2008

  • Ototoxicity of trichloroethylene in concentrations relevant for the working environment

    Vyskocil A., Leroux T., Truchon G., Lemay F., Gagnon F., Gendron M., Viau C.

    Source :

    Human & Experimental Toxicology, vol. 27, no 3, 2008, p. 195-200

  • Occupational ototoxicity of n-hexane

    Vyskocil A., Leroux T., Truchon G., Gendron M.

    Source :

    Human & Experimental Toxicology, vol. 27, no 6, 2008, p. 471-476

  • Ethyl benzene should be considered ototoxic at occupationally relevant exposure concentrations

    Vyskocil A., Leroux T., Truchon G., Lemay F., Gagnon F., Gendron M., Gagnon F., El Majidi N., Viau C.

    Source :

    Toxicology and Industrial Health, vol. 24, no 4, 2008, p. 241-246

  • Effects of occupational exposure to chemicals on hearing - a weight of evidence approach

    Vyskocil A., Truchon G., Leroux T., Lemay F., Lim S., Gagnon F., Viau C.

    Source :

    Toxicological Sciences, vol. 102, no 1-S, 2008, p. 128

  • Assessment of the occupational ototoxicity of n-hexane

    Vyskocil A., Leroux T., Truchon G., Lemay F., Gendron M., Gagnon F., El Majidi N., Viau C.

    Source :

    Toxicology Letters, vol. 180, Suppl. 1, 2008, p. S150

  • Ototoxicity of trichloroethylene in concentrations relevant for the working environment (Poster)

    Vyskocil A., El Majidi N., Leroux T., Truchon G., Lemay F., Gendron M., Gagnon F., Viau C.

    Source :

    in Recherche en santé et sécurité du travail en action : méthodes, résultats et applications : Congrès en santé et sécurité du travail / ACRST-RRSSTQ, (15-17 juin, 2008 : Montréal, Canada), 2008

  • Assessment of the occupational ototoxicity of n-hexane

    Vyskocil A., Leroux T., Truchon G., Lemay F., Gendron M., Gagnon F., El Majidi N., Viau C.

    Source :

    in Eurotox 2008 : 45th Congress of The European Societies of Toxicology (October 5-8, 2008 : Rhodes, Greece), 2008

Additional Information

Type: Project
Number: 0099-5420
Status: Completed
Year of completion: 2009
Team:
  • Ginette Truchon (IRSST)
  • Adolf Vyskocil (Université de Montréal)
  • Tony Leroux (Université de Montréal)
  • François Lemay (IRSST)
  • Jacques Blain (IRSST)
  • Martine Gendron (Université de Montréal)