Effect of concentration peaks on the neurotoxicity of styrene in the reinforced fiberglass plastics industry – Phase II Abstract This project follows an initial phase that focused on the acute effects of styrene exposure and a critical analysis of the literature. This time, the authors wanted to determine whether exposure to high concentrations of this solvent, even for short periods, has harmful consequences on the health of workers who are regularly exposed to it. Their work was carried out on workers exposed to styrene in fibreglass reinforced plastics industries, at average concentrations not exceeding the time-weighted average exposure value (TWAEV) of 213 mg/m3.In this type of industry, major styrene exposure peaks were observed. In some cases, the measured values exceeded the standards specified by the Regulation respecting occupational health and safety (ROHS). It appears that at the exposure concentrations described, and for the exposure duration of the workers who participated in this study, styrene has no appreciable effect on the neurosensory and neuropsychological tests used by the researchers.According to the authors, these results, in contrast to others published in the scientific literature, do not justify lowering the Québec exposure standards for styrene for workers exposed under conditions similar to those in their cohort. Produced Under this Project Scientific Reports Effects of Concentration Peaks on Styrene Neurotoxicity in the Fibreglass Reinforced Plastics Industry - Phase II Research Report: R-640, R-728 Simplified Articles Les pics de concentration du styrène sont-ils dangereux ?Industrie du plastique renforcé Volume 24, n0 1 Scientific Publications Prédiction des concentrations de styrène dans le sang et dans le cerveau chez des travailleurs exposés à des pics de concentration de styrène à l'aide de la modélisation toxicocinétique à base physiologiqueMuray K., Tardif R., Thuot R., Charest-Tardif G., Viau C., Vyskocil A.Source : in La société des savoirs : 72e Congrès de l'Association canadienne-française pour l'avancement des sciences / ACFAS (72e : 10-14 mai, 2004 : Montréal, Canada), 2004Simple device to improve styrene peak concentrations measurements using a portable gas chromatograph (PGC)Thuot R., Viau C., Vyskocil A.Source : in X2004 "Exposure Assessment in a Changing Environment" (June 16-18, 2004 : Utrecht, The Netherlands), 2004Rôle de l'approche toxicocinétique à base physiologique (tcbp) dans la prédiction de concentrations de styrène dans le sang et au cerveau des travailleurs exposés au styrèneMuray K., Tardif R., Thuot R., Charest-Tardif G., Viau C., Vyskocil A.Source : in Colloque annuel CIRTOX 2004 (20 mai, 2004 : Montréal, Canada), 2004Une astuce pour un échantillonnage fiable des pointes de concentration de styrène à l'a ide d'un chromatographe en phase gazeuse portatifThuot R., Viau C., Vyskocil C.Source : in La SST de la pratique à l’intégration…un défi ! : 27e congrès de l’Association québécoise pour l’hygiène, la santé et la sécurité du travail / AQHSST (27e : 17-19 mai, 2005 : St-Hyacinthe, Canada), 2005Effects of peak concentrations on the neurotoxicity of styrene in workersEl Majidi N., Vyskocil A., Thuot R., Beaudry C., Charest-Tardif G., Tardif R., Gagnon F., Ska B., Turcot A., Viau C.Source : Toxicology Letters, vol. 196, suppl. 1, 2010, p. S71Are peak workplace exposures associated with styrene neurotoxicity?El Majidi N., Vyskocil A., Thuot R., Beaudry C., Charest-Tardif G., Tardif R., Gagnon F., Ska B., Turcot A., Viau C.Source : in Annual Meeting of the Society of Toxicology, (50th : March 6-10 : Washington, USA), 2011 Additional Information Type: Project Number: 0099-2210 Status: Completed Year of completion: 2010 Research Field: Chemical and Biological Hazard Prevention Team: Adolf Vyskocil (Université de Montréal)Claude Viau (Université de Montréal)Bernadette Ska (Université de Montréal)Michel Gérin (Université de Montréal)Robert Tardif (Université de Montréal)Ginette Truchon (IRSST)