N-Nitrosodimethylamine

According to Decree 280-2024 published on February 28, 2024, in the Gazette officielle du Québec, the amendment to the Appendix 1 of the Regulation respecting occupational health and safety (RSST, RLRQ, c. S-2.1, r. 13) will come into force on March 14, 2024. These regulatory changes have not yet been incorporated into the current Substance Data Sheets of the Sampling Guide for Air Contaminants in the Workplace. An update is currently underway and will be available as soon as possible. Consequently, the information contained in the data sheets of substances modified or added in Decree 280-2024 is partially inaccurate or incomplete. Please consult our infoLABO (in French only) for more details. Please contact our client service: [email protected] for further information.

N-Nitrosodimethylamine

French name in the regulation: N-Nitrosodiméthylamine

CAS : 62-75-9

Exposure Standards in RROHS regulation

Permissible exposure values (PEV)

	ppm	mg/m³	f/cc	Notes
TWAEV	-	-	-	-
STEV	-	-	-	-
Ceiling	-	-	-	-

Carcinogenicity	C2	Sensitizer
Simple asphyxiant		Percutaneous
Prohibited use		Prohibited recirculation
Minimum exposure		Explosion hazard
Ototoxic

TWA adjustment for unusual work schedules

III : Weekly adjustment

CNESST – Toxicological Index Service

Consult REPTOX file: N-Nitrosodimethylamine

Analysis:

N-Nitrosodiméthylamine (NDMA)

Method: IRSST - 371

Sampling protocol

Sampling device:
Sampling media required:

#IRSST	Description
2210	Florisil tube with pre-tube

Parameters:
Flow rate: 1-2 L/min
TWA sampling volume: 1000 L
STEL sampling volume: -
Remarks: The recommended sampling volume is 400 to 1000 litres. The samples can be kept for 4 weeks in the dark at 4°C.The simulltaneous determination of 8 nitrosamines can be done on the same tube.

Analytical protocol

Principle: Gas chromatography with nitrogen-phosphorus detection (GC-NPD)
Precision (%): 3,3
Minimum reported value: 0,04 µg

Reference

IRSST. "Analyse des nitrosamines dans l'air". Méthode 371. Non publiée.